Mbale Clinical Research Institute

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2020 Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants.

Paulson JN, Williams BL, Hehnly C, Mishra N, Sinnar SA, Zhang L, Ssentongo P, Mbabazi- Kabachelor E, Wijetunge DSS, von Bredow B, Mulondo R, Kiwanuka J, Bajunirwe F, Bazira J, Bebell LM, Burgoine K, Couto-Rodriguez M, Ericson JE, Erickson T, Ferrari M, Gladstone M, Guo C, Haran M, Hornig M, Isaacs AM, Kaaya BN, Kangere SM, Kulkarni AV, Kumbakumba E, Li X, Limbrick DD Jr, Magombe J, Morton SU, Mugamba J, Ng J, Olupot-Olupot P, Onen J, Peterson MR, Roy F, Sheldon K, Townsend R, Weeks AD, Whalen AJ, Quackenbush J, Ssenyonga P, Galperin MY, Almeida M, Atkins H, Warf BC, Lipkin WI, Broach JR, Schiff SJ.Sci Transl Med. 2020 Sep 30;12(563):eaba0565. doi:10.1126/scitranslmed.aba0565.PMID: 32998967

2019 Transfusion Timing and Volume in African Children with Severe Anemia. Reply. Maitland K, Olupot-Olupot P, Walker AS. N Engl J Med. 2019 Oct 24;381(17):1687-1688. doi: 10.1056/NEJMc1911668.PMID: 31644854

2019 Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial. Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Nabawanuka E, Sennyondo T, Aromut D, Kumwenda F, Musika CW, Thomason MJ, Bates I, von Hensbroek MB, Evans JA, Uyoga S, Williams TN, Frost G, George EC, Gibb DM, Walker AS; TRACT trial group.Lancet Glob Health. 2019 Oct; 7(10):e1435-e1447. doi: 10.1016/S2214-109X(19)303456. PMID:31537373

2019 Reducing preterm mortality in Eastern Uganda: the impact of introducing low-cost bubble CPAP on neonates <1500g. Okello F, Egiru E, Ikiror J, Acom L, Loe K, Olupot-Olupot P, Burgoine K. BMC Pediatr. 2019 Sep 4;19(1):311. doi: 10.1186/s12887-019-1698-x.PMID:31484567

2019 Neonatal tetanus in eastern Uganda: improved outcome following the implementation of a neonatal tetanus protocol. Burgoine K, Egiru E, Ikiror J, Acom L, Akol S, Olupot-Olupot P. Trop Doct. 2019 Aug 31:49475519872860. Doi: 10.1177/0049475519872860. [Epub ahead of print] PMID: 31474192

2019 Educational Curricula and Programs in Adolescent Medicine for Health Workers in Low- and Middle-Income Countries: A Scoping Review. Miller KK, Brown SJ, Pfeffer B, Olupot-Olupot P, Kitaka S. J Grad Med Educ. 2019 Aug;11(4 Suppl):64-72. Doi: 10.4300/JGME-D-19-00052. Review. PMID: 31428260

2019 Neonatal tetanus in eastern Uganda: improved outcome following the implementation of a neonatal tetanus protocol. Burgoine K, Egiru E, Ikiror J, Acom L, Akol S, Olupot-Olupot P. Trop Doct. 2019 Aug 31:49475519872860. Doi: 10.1177/0049475519872860. [Epub ahead of print] PMID: 31474192

2019 Educational Curricula and Programs in Adolescent Medicine for Health Workers in Low- and Middle-Income Countries: A Scoping Review. Miller KK, Brown SJ, Pfeffer B, Olupot-Olupot P, Kitaka S. J Grad Med Educ. 2019 Aug;11(4 Suppl):64-72. Doi: 10.4300/JGME-D-19-00052. Review. PMID: 31428260

2019 Transfusion Volume for Children with Severe Anemia in Africa.

Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Uyoga S, Kyeyune Byabazaire D, M'baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, Saramago Goncalves P, George EC, Gibb DM, Walker AS; TRACT Group. N Engl J Med. 2019 Aug 1 ; 38 1(5):420-431. doi:10.1056/NEJMoa1900100.PMID:3-1365800

2019 Immediate Transfusion in African Children with Uncomplicated Severe Anemia.

Maitland K, Kiguli S, Olupot-Olupot P, Engoru C, Mallewa M, Saramago Goncalves P, Opoka RO, Mpoya A, Alaroker F, Nteziyaremye J, Chagaluka G, Kennedy N, Nabawanuka E, Nakuya M, Namayanja C, Uyoga S, Kyeyune Byabazaire D, M'baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, George EC, Gibb DM, Walker AS; TRACT Group. N Engl J Med. 2019 Aug 1; 381(5):407-419. doi: 10.1056/NEJMoa1900105.PMID:31365799

2019 Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration?

Houston KA, Gibb J, Olupot-Olupot P, Obonyo N, Mpoya A, Nakuya M, Muhindo R, Uyoga S, Evans JA, Connon R, Gibb DM, George EC, Maitland K. BMC Med. 2019 Jul 1; 17(1):122.

Doi: 10.1186/s12916-019-1356-z.PMID:31256761.

2019 A study using knowledge, attitude and practices on the prevention of HIV-1 vertical transmission with outcomes in early infant HIV-1 diagnosis in Eastern Uganda. Nsubuga S, Meadway J, Olupot- Olupot P. J Virus Erad. 2019 Apr 1; 5(2):102- 108.PMID:31191913

2019 Healthcare-provider perceptions of barriers to oxygen therapy for paediatric patients in three government-funded eastern Ugandan hospitals; a qualitative study. Dauncey JW, Olupot-Olupot P, Maitland K. BMC Health Serv Res. 2019 May 24; 19(1):335. Doi: 10.1186/s12913-019-4129-7. PMID:31126269

2019 Baby Gel pilot: a pilot cluster randomized trial of the provision of alcohol hand gel to postpartum mothers to prevent neonatal and young infant infection-related morbidity in the community. Ditai J, Abeso J, Odeke NM, Mobbs N, Dusabe-Richards J, Mudoola M, Carrol ED, Olupot-Olupot P, Storr J, Medina-Lara A, Gladstone M, Faragher EB, Weeks AD. Pilot Feasibility Study. 2019 Mar 26; 5:49. doi: 10.1186/s40814-019-0432-7. eCollection 2019. PMID:30962946

2019 Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda.

Olupot-Olupot P, Prevatt N, Engoru C, Nteziyaremye J, Amorut D, Chebet M, Senyondo T, Ongodia P, Ndila CM, Williams TN, Maitland K.Version 2. Wellcome Open Res. 2019 Mar 18

10.12688/wellcomeopenres.14801.2. eCollection 2018.PMID:30854471

2019 Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda.

Olupot-Olupot P, Prevatt N, Engoru C, Nteziyaremye J, Amorut D, Chebet M, Senyondo T, Ongodia P, Ndila CM, Williams TN, Maitland K. Version 2. Wellcome Open Res. 2019 Mar 18 [revised 2019 Jan 1];3:130. doi: 10.12688/wellcomeopenres.14801.2. eCollection 2018.PMID:30854471

2019 In search of a primary outcome for community-based newborn infection trials in Eastern Uganda: a nested cohort study within the BabyGel pilot trial. Mobbs NA, Ditai J, Abeso J, Faragher EB, Carrol ED, Gladstone M, Medina-Lara A, Olupot-Olupot P, Weeks AD. Pilot Feasibility Study. 2019 Mar 13;5:43. doi: 10.1186/s40814-019-0428-3. eCollection 2019.PMID:30911406

2019 Hematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa. Uyoga S, Mpoya A, Olupot-Olupot P, Kiguli S, Opoka RO, Engoru C, Mallewa M, Kennedy N, M'baya B, Kyeyune D, Wabwire B, Bates I, Gibb DM, Walker AS, George EC, Williams TN, Maitland K.Vox Sang. 2019 May; 114(4):340-348. doi: 10.1111/vox.12764. Epub 2019 Mar 5.PMID: 30838664

2018 Optimizing informed consent for participants in a randomized controlled trial in rural Uganda: a comparative prospective cohort mixed-methods study. Ditai J, Kanyago J, Nambozo MR, Odeke NM, Abeso J, Dusabe-Richards J, Olupot-Olupot P, Carrol ED, Medina-Lara A, Gladstone M, Storr J, Faragher B, Weeks AD. Trials. 2018 Dec 22; 19(1):699. doi: 10.1186/s13063-018-3030-8. PMID: 30577809

2018 Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa. Tshilolo L, Tomlinson G, Williams TN, Santos B, Olupot-Olupot P, Lane A, Aygun B, Stuber SE, Latham TS, McGann PT, Ware RE; REACH Investigators. N Engl J Med. 2019 Jan 10;380(2):121-131. doi: 10.1056/NEJMoa1813598. Epub 2018 Dec 1. PMID: 30501550

2018 Preventing neonatal sepsis in rural Uganda: a cross-over study comparing the tolerance and acceptability of three alcohol-based hand rub formulations. Ditai J, Mudoola M, Gladstone M, Abeso J, Dusabe-Richards J, Adengo M, Olupot-Olupot P, Carrol ED, Storr J, Medina-Lara A, Faragher B, Weeks AD. BMC Public Health. 2018 Nov 20;18(1):1279. doi: 10.1186/s12889-018-6201-3 PMID: 30458740

2018 Bacterial Aetiology and Antibiotic Susceptibility Profile of Post-Operative Sepsis among Surgical Patients in a Tertiary Hospital in Rural Eastern Uganda. George M, Iramiot JS, Muhindo R, Olupot- Olupot P, Nanteza A. Microbiol Res J Int. 2018;24(2). pii: MRJL.41690. doi: 10.9734/MRJI/2018/41690. Epub 2018 Jun 20. PMID: 30370374

2018 Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial. Walsh K, Calder N, Olupot-Olupot P, Ssenyondo T, Okiror W, Okalebo CB, Muhindo R, Mpoya A, Holmes E, Marchesi J, Delamare de la Villenaise de Chenevarin G, Frost G, Maitland K. Wellcome Open Res. 2018 Aug 2; 3:95. doi: 10.12688/wellcomeopenres.14706.1. eCollection 2018. PMID: 3034538

2018 Asymptomatic Plasmodium Parasites among Adults in Eastern Uganda: A Case of Donor Blood Screening at Mbale Regional Blood Bank. Inyimai SP, Ocan M, Wabwire B, Olupot-Olupot P. J Trop Med. 2018 Jul 9;2018:6359079. doi: 10.1155/2018/6359079. eCollection 2018. PMID: 30112007

2018 Neonatal and congenital malaria: a case series in malaria endemic eastern Uganda.

Olupot-Olupot P, Eregu EIE, Naizuli K, Ikiror J, Acom L, Burgoine K. Malar J. 2018 Apr 20;17(1):171. doi: 10.1186/s12936-018-2327-0. PMID:29678190

2018 Staged implementation of a two-tiered hospital-based neonatal care package in a resource-limited setting in Eastern Uganda. Burgoine K, Ikiror J, Akol S, Kakai M, Talyewoya S, Sande A, Otim T, Okello F, Hewitt-Smith A, Olupot-Olupot P.

BMJ Glob Health. 2018 Feb 19; 3(1):e000586. doi: 10.1136/bmjgh-2017-000586.

eCollection 2018.

2018 Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa. Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P, Opoka RO Engoru C, Akech SO, Nyeko R, Mtove G, Gibb DM, Babiker AG, Maitland K. BMC Med. 2018 Mar 9;16(1):37. doi: 10.1186/s12916-018-1014-x.

2018 Where have all the children gone? High HIV prevalence in infants attending

Nutrition and inpatient entry points. Kiyaga C, Urick B, Fong Y, Okiira C, Nabukeera - Barungi N, Nansera D, Ochola E, Nteziyaremye J, Bigira V, Ssewanyana I, Peter Olupo- Olupot , Peter T, Ghadrshenas A, Vojnov L Int AIDS Soc. 2018 Feb; 21(2). doi: 10.1002/jia2.25089.

2018 Reagent Strips as an Aid to Diagnosis of Neonatal Meningitis in a Resource-limited setting.

Burgoine K, Ikiror J, Naizuli K, Achom L, Akol S, Olupot-Olupot P.

J Trop Pediatr. 2018 Jan 29. doi: 10.1093/tropej/fmy003. [Epub ahead of print].

2018 Children's Oxygen Administration Strategies Trial (COAST): A randomized controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna, P Bandika V, Mpoya A, Bush A, Williams TN, Grieve R, Sadique Z, Harrison D, Rowan K Wellcome Open Res. 2017 Oct 11;2:100. doi: 10.12688/wellcomeopenres.12747.1. eCollection 2017.

2018 Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa. McGann PT, Williams TN, Olupot- Olupot P, Tomlinson GA, Lane A, Luís Reis da Fonseca J, Kitenge R, Mochamah G, Wabwire H, Stuber S, Howard TA, McElhinney K, Aygun B, Latham T, Santos B, Tshilolo L, Ware RE; REACH Investigators. Am J Hematol. 2018 Aug;93(4):537- 545. doi: 10.1002/ajh.25034. Epub 2018 Jan 27.

2018 Assessment of Myocardial Function and Injury by Echocardiography and Cardiac

Biomarkers in African Children with Severe Plasmodium falciparum Malaria. Kotlyar S, Olupot- Olupot P, Nteziyaremye J, Akech SO, Uyoga S, Muhindo R, Moore CL, Maitland K. Pediatr Crit Care Med. 2018 Mar; 19(3):179-185. doi: 10.1097/PCC.0000000000001411.

2018 Rapid Serological Tests Ineffectively Screen for HIV Exposure in HIV-Positive Infants. Urick B, Fong Y, Okiira C, Nabukeera-Barungi N, Nansera D, Ochola E, Nteziyaremye J, Bigira V, Ssewanyana I, Olupot-Olupot P, Peter T, Ghadrshenas A, Vojnov L, Kiyaga C. J Acquir Immune Defic Syndr. 2018 Mar 1; 77(3):331-336. doi: 10.1097/QAI.0000000000001609.

2017 The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study. Nardo-Marino A, Williams TN, Olupot-Olupot P. BMC Hematol. 2017 Sep 7; 17:14. doi: 10.1186/s12878-017-0085-9. eCollection 2017.PMID: 28912951.

2017 Gastroenteritis Aggressive Versus Slow Treatment for Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration. Houston KA, Gibb JG, Mpoya

A, Obonyo N, Olupot-Olupot P, Nakuya M, Evans JA, George EC, Gibb DM, Maitland K. Wellcome Open Res. 2017 Aug 10;2:62. doi: 10.12688/wellcomeopenres.12261.1. eCollection 2017. PMID: 28905004.

2015 Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia. Peter Olupot-Olupot, Charles Engoru, Jennifer Thompson, Julius Nteziyaremye, Martin Chebet, Tonny Ssenyondo, Cornelius M Dambisya, Vicent Okuuny, Ronald Wokulira, Denis Amorut, Paul Ongodia, Ayub Mpoya, Thomas N Williams, Sophie Uyoga, Alex Macharia, Diana M Gibb, A Sarah Walker and Kathryn Maitland. BMC Medicine. 2014, 12:67.

2014 Spleen volume and clinical disease manifestations of severe plasmodium falciparum malaria in African children. Kotlyar S, Nteziyaremye J, Olupot-Olupot P, Akech SO, Moore CL, Maitland K. Trans R Soc Trop Med Hyg. 2014 May; 108(5): 283-9.

2014 Authors’ reply to Southhall. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N, Reyburn H, Levin M, George EC, South A, Babiker AG, Gibb DM, Maitland K. BMJ. 2014 Feb 19; 348

2014 WHO guidelines on fluid resuscitation in children: missing the FEAST data.

Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N, Reyburn H, Levin M, George EC,South A, Babiker AG, Gibb DM, Maitland K. BMJ. 2014; 348.

2013 Management of severe malaria: results from the recent trials. Peter Olupot - Olupot, Kathryn Maitland.

Advances in Experimental Medicine and Biology, Vol: 764.

2013 Endotoxaemia is common in children with Plasmodium falciparum malaria. Peter Olupot-Olupot, Britta C Urban, Julie Jemutai, Julius Nteziyaremye, Harry M Fanjo, Henry Karanja, Japhet Karisa, Paul Ongodia, Patrick Bwonyo, Evelyn N Gitau, Alison Talbert, Samuel Akech and Kathryn Maitland. BMC Infect Dis. 2013 Mar 5; 13:117.

2013 Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. Kathryn Maitland, Elizabeth C George, Jennifer A Evans, Sarah Kiguli, Peter Olupot-Olupot, Samuel O Akech, Robert O Opoka, Charles Engoru, Richard Nyeko, George Mtove, Hugh Reyburn, Bernadette Brent, Julius Nteziyaremye, Ayub Mpoya, Natalie Prevatt, Cornelius M Dambisya, Daniel Semakula, Ahmed Ddungu, Vicent Okuuny, Ronald Wokulira, Molline Timbwa, Benedict Otii, Michael Levin, Jane Crawley, Abdel G Babiker, Diana M Gibb and for the FEAST trial group.

BMC Medicine. 2013 Mar 14; 11:68.

2013 The Words Will Pass with the Blowing Wind’: Staff and Parent Views of the Deferred Consent Process, with Prior Assent, Used in an Emergency Fluids Trial in Two African Hospitals Sassy Molyneux, Maureen Njue1, Mwanamvua Boga, Lilian Akello, Peter Olupot-Olupot, Charles Engoru, Sarah Kiguli, Kathryn Maitland. PLoS ONE, Volume 8, Issue 2, e54894. February 2013.

2011 Mortality after Fluid Bolus in African Children with Severe Infection. Kathryn Maitland, M.B., B.S., Ph.D., Sarah Kiguli, M.B., Ch.B., M.Med., Robert O. Opoka, M.B., Ch.B., M.Med., Charles Engoru,

M.B., Ch.B., M.Med., Peter Olupot-Olupot, M.B., Ch.B., Samuel O. Akech, M.B., Ch.B., Richard

Nyeko, M.B., Ch.B., M.Med., George Mtove, M.D., Hugh Reyburn, M.B., B.S., Trudie Lang, Ph.D., Bernadette Brent, M.B., B.S., Jennifer A. Evans, M.B., B.S., James K. Tibenderana, M.B., Ch.B., Ph.D., Jane Crawley, M.B., B.S., M.D., Elizabeth C. Russell, M.Sc., Michael Levin, F.Med.Sci., Ph.D., Abdel G. Babiker, Ph.D., and Diana M. Gibb, M.B., Ch.B., M.D. for the FEAST Trial Group. N Engl J Med. 2011; 364:2483-2495 June 30, 2011.

2009 Orphanhood predicts delayed access to care in Ugandan children. Ntanda H, Olupot-Olupot P, Mugyenyi P, Kityo C, Lowes R, Cooper C, Lima V, Mills E. Pediatr Infect Dis J 2009 Feb, 28:153-5.

2008 Implementing a hospital based injury surveillance system in Africa: lessons learned. Zavalaa DE, Bokongo S, John IA, Senoga IM, Mtonga RE, Mohammed AZ, Anjango WO, Olupot-Olupot P. Med ConflSurviv. 2008 Oct-Dec, 24:260-72.

2008 Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda. Kiboneka A, Wangisi J, Nabiryo C, Tembe J, Kusemererwa S, Olupot-Olupot P, Joffres M, Anema A, Cooper CL, Montaner JS, Mills EJ. AIDS 2008 Nov 30, 22:2493-9

2008 Chronic viral hepatitis may diminish the gains of HIV antiretroviral therapy in sub-Saharan Africa.

Cooper CL, Mills E, Wabwire BO, Ford N, Olupot-Olupot P. Int J Infect Dis. 2008 Nov 10.

2008 Adherence to antiretroviral therapy among a conflict-affected population in Northeastern Uganda: a qualitative study. Olupot-Olupot P, Katawera A, Cooper C, Small W, Anema A, Mills E AIDS. 2008 Sep 12, 22:1882-4.

2008 Pediatric HIV therapy in armed conflict. Kiboneka A, Nyatia RJ, Nabiryo C, Olupot-Olupot P, Anema A, Cooper C, Mills E. AIDS 2008 May 31, 22:1097-8.

2008 In eastern Uganda, training in Post Exposure Prophylaxis, (PEP) after occupational exposure to HIV produced better practice throughout the region. Obbo JSO, Olupot – Olupot Peter, Balyejjusa J &Meadway J: HIV Med. (2008) 9 (s1) 10 – 50 P5.

2007 A multinational injury surveillance system pilot project in Africa. Zavala DE, okongo S, John IA, Mpanga SI, Mtonga RE, Aminu ZM, Odhiambo W, OlupotOlupot P. J Public Health Policy 2007 Dec, 28:432-41.

2006 Was the "ABC" approach (abstinence, being faithful, using condoms) responsible for Uganda's decline in HIV? Murphy EM, Greene ME, Mihailovic A, Olupot-Olupot P. PLoS Med. 2006 Sep, 3:e379.

2006 Health implications of small arms and light weapons in eastern Uganda. Pinto AD, Olupot-Olupot P, Neufeld VR , Med ConflSurviv 2006 Jul-Sep, 22:207-219.