Mbale Clinical Research Institute

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The clinical trial mainly involves assessing the tolerability and safety of SLDPQ – Single Low Dose Primaquine in African Children with acute uncomplicated falciparum malaria and glucose 6 phosphate dehydrogenase deficiency.

TABS PKPD is clinical trial involving the investigation of Pharmacokinetics and Pharmacodynamics of Azithromycin in severe malaria and bacterial co-infection in African Children.


FLACSAM stands for Firstline Antimicrobials in Children with Complicated Severe Acute Malnutrition. The study compares antibiotics used in managing infections in children. This is a clinical trial comparing effectiveness of antibiotics used to treat children with complicated severe acute malnutrition.


Gastroenteritis is a very common cause of diarrhea and vomiting. It is most likely to be caused by a bacterial or viral stomach infection and is particularly common in young children. This trial study is conducted at MCRI. In some cases, it can cause severe dehydration, a condition that requires immediate medical treatment.


This is an open, multicenter Randomized Controlled Trial of 840 participants, aged from 6months to 12 years, admitted with severe pneumonia, respiratory distress complicated by hypoxia (saturations<92%).This trial will investigate in these children whether supplementary feeding for 56 days (8weeks) using Ready to Use Therapeutic feeds (RUTAFA) in addition to the usual diet verses standard of care (usual diet alone) will improve primary and secondary outcomes at 90 days and 180 days. Children admitted to hospital with severe pneumonia and hypoxia are at risk of poor long term outcomes, where undernutrition is a risk factor. We aim to investigate whether nutritional support is an important adjunctive treatment for such children.


The Open Cohort Study (COCS), aims at refining COVID-19 case definitions, establish incidence of the pandemic and to characterize the clinical spectrum and outcomes of the disease among different populations.


The Children’s Oxygen Administration Strategies Trial (COAST) was an open, multicenter fractional Randomized Control Trial (RCT) of 4200 participants aged between 28 days and 12 years, admitted to hospital with respiratory distress complicated by hypoxia. The COAST Trial was investigating what the best oxygen delivery strategies were, to reduce in – hospital mortality and mobility in African Children with respiratory distress complicated by Hypoxia.

This procedure was being done by evaluating two linked components of oxygen delivery to establish whether liberal oxygenation is superior to permissive hypoxia (current routine standard of care in hospitals not screening all admissions for Hypoxia) and to establish weather high flow oxygen delivery was better than low flow oxygen delivery (current routine standard of care in hospitals with no access to mechanical ventilation).